Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

Obesity, a pandemic disease, is caused by an excessive accumulation of fat that can have
detrimental effects on health. Adipose tissue plays a very important endocrine role, secreting …

Abstract Purpose of Review In this review, we investigate the role of classic and novel
adipocytokines in cancer pathogenesis synopsizing the mechanisms underlying the …

Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the
brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The …

Apelin is an endogenous ligand of the apelin receptor (APJ), a seven-transmembrane G
protein-coupled receptor. Apelin/APJ system has a wide tissue distribution in the brain as …

Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in
angiogenesis has been well documented, the ability of the apelin/APJ system to induce …

Cancer is a disease that seriously endangers human health and is mainly characterized by
a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of …

Background To study the association between Apelin expression and the clinical features
and postoperative prognosis in patients with gastric cancer (Int J Cancer 136: 2388-2401 …

Bevacizumab (bvz) is currently employed as an anti-angiogenic therapy across several
cancer indications. Bvz response heterogeneity has been well documented, with only 10 …