[HTML][HTML] Tumor angiogenesis: causes, consequences, challenges and opportunities
R Lugano, M Ramachandran, A Dimberg - Cellular and Molecular Life …, 2020 - Springer
Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …
vary between tumor type and anatomic location, but also occur simultaneously within the …
[HTML][HTML] The role of apelin in cardiovascular diseases, obesity and cancer
MB Wysocka, K Pietraszek-Gremplewicz… - Frontiers in …, 2018 - frontiersin.org
Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …
A role for novel adipose tissue‐secreted factors in obesity‐related carcinogenesis
B Cabia, S Andrade, MC Carreira… - Obesity …, 2016 - Wiley Online Library
Obesity, a pandemic disease, is caused by an excessive accumulation of fat that can have
detrimental effects on health. Adipose tissue plays a very important endocrine role, secreting …
detrimental effects on health. Adipose tissue plays a very important endocrine role, secreting …
Classic and novel adipocytokines at the intersection of obesity and cancer: diagnostic and therapeutic strategies
Abstract Purpose of Review In this review, we investigate the role of classic and novel
adipocytokines in cancer pathogenesis synopsizing the mechanisms underlying the …
adipocytokines in cancer pathogenesis synopsizing the mechanisms underlying the …
Role of Apelin/APJ axis in cancer development and progression
J Masoumi, A Jafarzadeh, H Khorramdelazad… - Advances in medical …, 2020 - Elsevier
Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the
brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The …
brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The …
Apelin/APJ system and cancer
Y Yang, SY Lv, W Ye, L Zhang - Clinica chimica acta, 2016 - Elsevier
Apelin is an endogenous ligand of the apelin receptor (APJ), a seven-transmembrane G
protein-coupled receptor. Apelin/APJ system has a wide tissue distribution in the brain as …
protein-coupled receptor. Apelin/APJ system has a wide tissue distribution in the brain as …
[HTML][HTML] Apelin promotes lymphangiogenesis and lymph node metastasis
J Berta, MA Hoda, V Laszlo, A Rozsas, T Garay… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in
angiogenesis has been well documented, the ability of the apelin/APJ system to induce …
angiogenesis has been well documented, the ability of the apelin/APJ system to induce …
Roles of apelin/APJ system in cancer: Biomarker, predictor, and emerging therapeutic target
J Chen, Z Li, Q Zhao, L Chen - Journal of Cellular Physiology, 2022 - Wiley Online Library
Cancer is a disease that seriously endangers human health and is mainly characterized by
a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of …
a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of …
[HTML][HTML] Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer
M Feng, G Yao, H Yu, Y Qing, K Wang - BMC cancer, 2016 - Springer
Background To study the association between Apelin expression and the clinical features
and postoperative prognosis in patients with gastric cancer (Int J Cancer 136: 2388-2401 …
and postoperative prognosis in patients with gastric cancer (Int J Cancer 136: 2388-2401 …
[HTML][HTML] Apelin: a putative novel predictive biomarker for bevacizumab response in colorectal cancer
L Zuurbier, A Rahman, M Cordes, J Scheick, TJ Wong… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Bevacizumab (bvz) is currently employed as an anti-angiogenic therapy across several
cancer indications. Bvz response heterogeneity has been well documented, with only 10 …
cancer indications. Bvz response heterogeneity has been well documented, with only 10 …