Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Classical Hodgkin lymphoma (cHL) and anaplastic lymphoma kinase-positive, anaplastic
large cell lymphoma (ALK+ ALCL) are B and T cell lymphomas respectively, which express …

Deficiency in DNA double-strand break (DSB) repair mechanisms has been widely exploited
for the treatment of different malignances, including homologous recombination (HR) …

The dual ALK/MET inhibitor crizotinib was recently approved for the treatment of metastatic
and late-stage ALK+ NSCLC, and is currently in clinical trial for other ALK-related diseases …

The phosphatidylinositide-3 kinases and the downstream mediator AKT drive survival and
proliferation of multiple myeloma (MM) cells. AKT signaling is active in MM and has …

The mechanisms underlying the pathogenesis of the constitutively active tyrosine kinase
nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expressing anaplastic large cell …

MALT1 is the only known paracaspase and is a critical mediator of B-and T-cell receptor
signalling. The function of the MALT1 gene is subverted by oncogenic chimeric fusions …

Anaplastic large cell lymphoma (ALCL) comprises a group of T-cell non-Hodgkin
lymphomas unified by common morphologic and immunophenotypic characteristics, but with …

Neuroblastoma is a common extracranial solid tumour of childhood, responsible for 15% of
cancer-related deaths in children. Prognoses vary from spontaneous remission to …

Background We have previously described the existence of two phenotypically distinct cell
subsets in ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) based on their …