Biocompatible long-sustained release oil-core polyelectrolyte nanocarriers: From controlling physical state and stability to biological impact

K Szczepanowicz, U Bazylińska, J Pietkiewicz… - Advances in Colloid and …, 2015 - Elsevier
It has been generally expected that the most applicable drug delivery system (DDS) should
be biodegradable, biocompatible and with incidental adverse effects. Among many micellar …

Polymer capsules with hydrophobic liquid cores as functional nanocarriers

J Szafraniec-Szczęsny, M Janik-Hazuka, J Odrobińska… - Polymers, 2020 - mdpi.com
Recent developments in the fabrication of core-shell polymer nanocapsules, as well as their
current and future applications, are reported here. Special attention is paid to the newly …

Co-delivery system based on multilayer structural nanoparticles for programmed sequential release of fucoxanthin and curcumin

L Wang, Z Wei, C Xue, L Yang - Food Hydrocolloids, 2023 - Elsevier
Multilayer structural nanoparticles (MSNPs) fabricated by gliadin (Gli), carboxymethyl konjac
glucomannan (CMK) and chitosan hydrochloride (CHC) were used to co-encapsulate …

pH-induced changes in polypeptide conformation: Force-field comparison with experimental validation

P Batys, M Morga, P Bonarek… - The Journal of Physical …, 2020 - ACS Publications
Microsecond-long all-atom molecular dynamics (MD) simulations, circular dichroism, laser
Doppler velocimetry, and dynamic light-scattering techniques have been used to investigate …

Carboxymethyl konjac glucomannan coating on multilayered emulsions for improved bioavailability and targeted delivery of curcumin

LH Wang, JX Xiao, XD Li, GQ Huang - Food & Function, 2021 - pubs.rsc.org
Curcumin was entrapped in multilayered emulsions to increase its stability and
bioavailability. Curcumin emulsion stabilized by whey protein isolate (WPI) was coated with …

Pegylated polyelectrolyte nanoparticles containing paclitaxel as a promising candidate for drug carriers for passive targeting

K Szczepanowicz, M Bzowska, T Kruk… - Colloids and Surfaces B …, 2016 - Elsevier
Targeted drug delivery systems are of special importance in cancer therapies, since serious
side effects resulting from unspecific accumulation of highly toxic chemotherapeutics in …

Hybrid Polyelectrolyte/Fe3O4 Nanocapsules for Hyperthermia Applications

L Cristofolini, K Szczepanowicz, D Orsi… - Acs Applied Materials …, 2016 - ACS Publications
We validated here the applicability to hyperthermia treatment of magnetic nanocapsules
prepared by the sequential layer-by-layer adsorption of polyelectrolytes and magnetic …

Encapsulation of clozapine in polymeric nanocapsules and its biological effects

S Łukasiewicz, K Szczepanowicz, K Podgórna… - Colloids and Surfaces B …, 2016 - Elsevier
Clozapine is an effective atypical antipsychotic drug that unfortunately exhibits poor oral
bioavailability. Moreover, the clinical use of the compound is limited because of its …

Polyelectrolyte nanocapsules containing iron oxide nanoparticles as MRI detectable drug delivery system

K Szczepanowicz, P Piechota, WP Węglarz… - Colloids and Surfaces A …, 2017 - Elsevier
The term “theranostic” has been designated for a material that combines the modalities of
therapy and diagnostics. For example, theranostic nanoparticles deliver therapeutic drugs …

The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent …

J Chwastek, D Jantas, W Lasoń - … Journal of Biochemistry & Cell Biology, 2017 - Elsevier
The role of the kinase ataxia-telangiectasia mutated (ATM), a well-known protein engaged in
DNA damage repair, in the regulation of neuronal responses to oxidative stress remains …