Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or
ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists …

The large family of C-type lectin (CLEC) receptors comprises carbohydrate-binding proteins
that require Ca2+ to bind a ligand. The prototypic receptor is the asialoglycoprotein receptor …

Introduction Defects of platelet functional responses in COVID-19 were reported, but their
origin and pathophysiological significance are unclear. The objective of this study was to …

The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous
thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on …

The hematological effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) are important in COVID-19 pathophysiology. However, the interactions of SARS-CoV-2 …

The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs,
including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the …

Conclusions Some of the platelet responses are critical for platelet plug formation (integrins,
dense granules, thromboxane A2), while others are involved in blood coagulation …

Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy that is
commonly associated with a life-threatening thrombocytopenic condition, Kasabach-Merritt …

C‐type lectins are a large superfamily of proteins involved in a multitude of biological
processes. In particular, their involvement in immunity and homeostasis has rendered them …

Background The process of thrombus formation is thought to involve interactions between
platelets and leukocytes. Leukocyte incorporation into growing thrombi has been well …