Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …

What happens precociously to the brain destined to develop Alzheimer's Disease (AD) still
remains to be elucidated and this is one reason why effective AD treatments are missing …

Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD),
amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy (SMA) are chronic …

Abstract Chemotherapy-Induced Peripheral Neuropathy (CIPN) is the most frequent adverse
effect of pharmacological cancer treatments. The occurrence of neuropathy prevents the …

We studied the properties of dopaminergic neurons in the substantia nigra pars compacta
(SN pc) and ventral tegmental area (VTA) in mice expressing the enhanced green …

Parkinson's disease (PD) is primarily associated with the progressive neurodegeneration of
the dopaminergic neurons in the substantia nigra region of the brain. The resulting motor …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is
characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra …

The altered function of the Hyperpolarization-activated Cyclic-Nucleotide-gated (HCN) ion
channels plays an important role in the pathogenesis of epilepsy in humans. In particular …

H-current, also known as hyperpolarization-activated current (Ih), is an inward current
generated by the hyperpolarization-activated cyclic nucleotide-gated (HCN) cation …