The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

The potential role of RNA N6-methyladenosine in Cancer progression

T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …

[HTML][HTML] METTL3 inhibits antitumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer

H Chen, Y Pan, Q Zhou, C Liang, CC Wong, Y Zhou… - Gastroenterology, 2022 - Elsevier
Background & Aims N 6-Methyladenosine (m 6 A) is the most prevalent RNA modification
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …

The interplay between m6A RNA methylation and noncoding RNA in cancer

S Ma, C Chen, X Ji, J Liu, Q Zhou, G Wang… - Journal of hematology & …, 2019 - Springer
Abstract N6-methyladenosine (m6A) methylation, one of the most common RNA
modifications, has been reported to execute important functions that affect normal life …

METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST

X Yang, S Zhang, C He, P Xue, L Zhang, Z He, L Zang… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m6A) is the most prevalent RNA epigenetic
regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is …

[HTML][HTML] The role of m6A RNA methylation in cancer

T Sun, R Wu, L Ming - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Abstract N6-methyladenosine (m6A), the most abundant internal modification of RNA in
eukaryotic cells, has gained increasing attention in recent years. The m6A modification …

YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer

J Li, H Xie, Y Ying, H Chen, H Yan, L He, M Xu, X Xu… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m 6 A) is the most abundant modification in
mRNA of humans. Emerging evidence has supported the fact that m 6 A is comprehensively …

Nanopore native RNA sequencing of a human poly (A) transcriptome

RE Workman, AD Tang, PS Tang, M Jain, JR Tyson… - Nature …, 2019 - nature.com
High-throughput complementary DNA sequencing technologies have advanced our
understanding of transcriptome complexity and regulation. However, these methods lose …

Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis

Z Song, G Jia, P Ma, S Cang - Life sciences, 2021 - Elsevier
Aims Exosomal transfer of miRNAs affects recipient cell proliferation and chemoresistance.
Here, we aimed to investigate the role of exosomal miRNAs in controlling cisplatin …

Accurate detection of m6A RNA modifications in native RNA sequences

H Liu, O Begik, MC Lucas, JM Ramirez… - Nature …, 2019 - nature.com
The epitranscriptomics field has undergone an enormous expansion in the last few years;
however, a major limitation is the lack of generic methods to map RNA modifications …