In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Abstract P2X receptor (P2XR) is a family of the ATP-gated ion channel family and can
permeabilize the plasma membrane to small cations such as potassium, sodium, and …

The purinergic receptor P2X7 is part of a complex signaling mechanism participating in a
variety of physiological and pathological processes. Depending on the activation scheme …

Macrophages and thymocytes express P2Z/P2X7nucleotide receptors that bind extracellular
ATP. These receptors play a role in immune development and control of microbial infections …

Abstract The P2X7 receptor (P2X7R), an ATP-gated cation channel, is expressed
predominantly in leukocytes. Activation of P2X7R has been implicated in the formation of a …

Stimulation of the P2X7 receptor by ATP induces cell membrane depolarization, increase in
intracellular Ca2+ concentration, and, in most cases, permeabilization of the cell membrane …

The general structure of the P2X7 receptor (P2X7R) is similar to the structure of other P2X
receptor family members, with the exception of its C terminus, which is the longest of this …

Macrophages express the P2X7 receptor and other nucleotide (P2) receptors, and display
the phenomenon of extracellular ATP (ATPe)-induced P2X7-dependent membrane …

Resident macrophages are tissue-specific innate immune cells acting as sentinels,
constantly patrolling their assigned tissue to maintain homeostasis, and quickly responding …

Given the role that extracellular ATP (ATPo)-mediated apoptosis may play in inflammatory
responses and in controlling mycobacterial growth in macrophages, we investigated …