Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze
reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic …

The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

How can we treat cancer more effectively? Traditionally, tumours from the same anatomical
site are treated as one tumour entity. This concept has been challenged by recent …

Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic
inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an …

Prostate cancer is the second most common cause of male cancer deaths in the United
States. However, the full range of prostate cancer genomic alterations is incompletely …

The advent of massively parallel sequencing technologies has allowed the characterization
of cancer genomes at an unprecedented resolution. Investigation of the mutational …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and
paraspeckles are membraneless subnuclear organelles. They are present at steady-state …

Abstract In the United States, prostate cancer (PCa) is the most commonly diagnosed non-
cutaneous cancer in males and the second leading cause of cancer-related death for men …