Review on Trypanosoma cruzi: Host Cell Interaction

W De Souza, TMU De Carvalho… - International journal of …, 2010 - Wiley Online Library
Trypanosoma cruzi, the causative agent of Chagas′ disease, which affects a large number
of individuals in Central and South America, is transmitted to vertebrate hosts by blood …

Trypanosoma cruzi surface mucins: host-dependent coat diversity

CA Buscaglia, VA Campo, ACC Frasch… - Nature Reviews …, 2006 - nature.com
The surface of the protozoan parasite Trypanosoma cruzi is covered in mucins, which
contribute to parasite protection and to the establishment of a persistent infection. Their …

Mechanisms of cellular invasion by intracellular parasites

DM Walker, S Oghumu, G Gupta, BS McGwire… - Cellular and molecular …, 2014 - Springer
Numerous disease-causing parasites must invade host cells in order to prosper.
Collectively, such pathogens are responsible for a staggering amount of human sickness …

Lactoferrin and its derived peptides: an alternative for combating virulence mechanisms developed by pathogens

D Zarzosa-Moreno, C Avalos-Gómez… - Molecules, 2020 - mdpi.com
Due to the emergence of multidrug-resistant pathogens, it is necessary to develop options to
fight infections caused by these agents. Lactoferrin (Lf) is a cationic nonheme multifunctional …

[HTML][HTML] Molecular basis of mammalian cell invasion by Trypanosoma cruzi

N Yoshida - Anais da Academia Brasileira de Ciencias, 2006 - SciELO Brasil
Establishment of infection by Trypanosoma cruzi, the agent of Chagas' disease, depends on
a series of events involving interactions of diverse parasite molecules with host components …

The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets

F Altamura, R Rajesh, CMC Catta‐Preta… - Drug development …, 2022 - Wiley Online Library
Human trypanosomiasis and leishmaniasis are vector‐borne neglected tropical diseases
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …

Chagas disease diagnostic applications: present knowledge and future steps

V Balouz, F Agüero, CA Buscaglia - Advances in parasitology, 2017 - Elsevier
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

Extracellular vesicles shed by Trypanosoma cruzi are linked to small RNA pathways, life cycle regulation, and susceptibility to infection of mammalian cells

MR Garcia-Silva, RF Cura das Neves… - Parasitology …, 2014 - Springer
The protozoan parasite Trypanosoma cruzi has a complex life cycle characterized by
intracellular and extracellular forms alternating between invertebrate and mammals. To cope …

The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles

A Acosta-Serrano, IC Almeida, LH Freitas-Junior… - Molecular and …, 2001 - Elsevier
Trypanosoma cruzi expresses at its surface large amounts of mucin-like glycoproteins. The
T. cruzi mucins (TcMUC), a group of highly glycosylated GPI-anchored proteins rich in Thr …

The evolution of two Trypanosoma cruzi subgroups inferred from rRNA genes can be correlated with the interchange of American mammalian faunas in the Cenozoic …

MRS Briones, RP Souto, BS Stolf, B Zingales - Molecular and biochemical …, 1999 - Elsevier
The agent of Chagas disease, Trypanosoma cruzi, is divided into two highly divergent
genetic subgroups, lineages 1 and 2, which include all typed strains isolated from humans …