Loss of pregnancy can occur at many different stages of gestation and for a variety of causes
but clearly produces a negative impact for reproductive and economic performances of dairy …

Maternal-to-embryonic transition (MET) is the period in early embryonic development when
maternal RNAs and proteins stored in the oocyte are gradually degraded and transcription …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

The human brain has enormously complex cellular diversity and connectivities fundamental
to our neural functions, yet difficulties in interrogating individual neurons has impeded …

Germ cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly,
piRNAs in mouse oocytes are relatively rare and dispensable. We present compelling …

Heat stress causes a large decline in pregnancy success per insemination during warm
times of the year. Improvements in fertility are possible by exploiting knowledge about how …

Worldwide over 5 million children have been conceived using assisted reproductive
technology, and research has concentrated on increasing the likelihood of ongoing …

Aberrant epigenetic reprogramming often results in developmental defects in somatic cell
nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight …

Background During mammalian pre-implantation embryonic development dramatic and
orchestrated changes occur in gene transcription. The identification of the complete changes …

PIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons.
Studies of the pathway in mice have strongly shaped the view that mammalian piRNAs are …