The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens
L Duan, Q Zheng, H Zhang, Y Niu, Y Lou… - Frontiers in …, 2020 - frontiersin.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
Analytical characterization of liposomes and other lipid nanoparticles for drug delivery
Y Fan, M Marioli, K Zhang - Journal of pharmaceutical and biomedical …, 2021 - Elsevier
Lipid nanoparticles, especially liposomes and lipid/nucleic acid complexed nanoparticles
have shown great success in the pharmaceutical industry. Their success is attributed to …
have shown great success in the pharmaceutical industry. Their success is attributed to …
[HTML][HTML] Controlling timing and location in vaccines
Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …
immune response induced by immunization arises following appropriate activation and …
[HTML][HTML] Fabrication of active targeting lipid nanoparticles: Challenges and perspectives
Targeted drug and gene delivery is the key for precision therapy. Lipid nanoparticles as non-
viral vectors have attracted extensive attentions in treating a variety of diseases, such as …
viral vectors have attracted extensive attentions in treating a variety of diseases, such as …
[HTML][HTML] Emerging vaccine nanotechnology: from defense against infection to sniping cancer
Looking retrospectively at the development of humanity, vaccination is an unprecedented
medical landmark that saves lives by harnessing the human immune system. During the …
medical landmark that saves lives by harnessing the human immune system. During the …
Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants
The omicron variants of SARS-CoV-2 have substantial ability to escape infection-and
vaccine-elicited antibody immunity. Here, we investigated the extent of such escape in nine …
vaccine-elicited antibody immunity. Here, we investigated the extent of such escape in nine …
Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection
KO Saunders, RJ Edwards, K Tilahun… - Science translational …, 2022 - science.org
A successful HIV-1 vaccine will require induction of a polyclonal neutralizing antibody (nAb)
response, yet vaccine-mediated induction of such a response in primates remains a …
response, yet vaccine-mediated induction of such a response in primates remains a …
Shaping humoral immunity to vaccines through antigen-displaying nanoparticles
Strategies to qualitatively and quantitatively enhance the humoral response to
immunizations with protein and polysaccharide antigens are of broad interest for …
immunizations with protein and polysaccharide antigens are of broad interest for …
Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine …
Uncleaved prefusion-optimized (UFO) design can stabilize diverse HIV-1 envelope
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …
Advances in nanomedicine for the treatment of infectious diseases caused by viruses
Viruses have a worldwide impact on healthcare and social and economic growth because
they are the largest cause of mortality due to infectious diseases. Furthermore, the long-term …
they are the largest cause of mortality due to infectious diseases. Furthermore, the long-term …