Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

Cells use actomyosin contractility to move through three-dimensional (3D) extracellular
matrices. Contractility affects the type of protrusions cells use to migrate in 3D, but the …

Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

A robust nanopillar platform with increased spatial resolution reveals that perinuclear forces,
originating from stress fibres spanning the nucleus of fibroblasts, are significantly higher on …

The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner
nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 …

Mechanical forces are known to influence cellular processes with consequences at the
cellular and physiological level. The cell nucleus is the largest and stiffest organelle, and it is …

The distinct spatial architecture of the apical actin cables (or actin cap) facilitates rapid
biophysical signaling between extracellular mechanical stimuli and intracellular responses …

Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …