Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Parasites such as Plasmodium and Toxoplasma possess a vestigial plastid homologous to
the chloroplasts of algae and plants. The plastid (known as the apicoplast; for apicomplexan …

Malaria continues to be a potentially fatal threat to almost half of the world's population. In
light of this threat, the armory to fight this disease is rather limited. Resistance against the …

The 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for isoprenoid biosynthesis has
come under increased scrutiny as a target for novel antimalarial, antibacterial and herbicidal …

The human malaria parasite Plasmodium falciparum is responsible for the deaths of more
than a million people each year. Fosmidomycin has been proven to be efficient in the …

The emergence and spread of drug resistance in the malaria parasite Plasmodium
falciparum as well as multi-and extremely drug-resistant forms of Mycobacterium …

The non-mevalonate pathway of isoprenoid (terpenoid) biosynthesis is essential in many
eubacteria including the major human pathogen, Mycobacterium tuberculosis, in …

The phylum Apicomplexa includes obligate intracellular parasites that cause both benign
and serious diseases. Human infection by Toxoplasma gondii can be asymptomatic but can …