Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …

Living materials, which are made either of or by living cells, or are synthetic materials with
programmable elements catered to cells, are environmentally responsive and can self …

To understand the diversity of immune responses to SARS-CoV-2 and distinguish features
that predispose individuals to severe COVID-19, we developed a mechanistic, within-host …

Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …

Oncolytic viruses (OVs) are emerging as promising and potential anti-cancer therapeutic
agents, not only able to kill cancer cells directly by selective intracellular viral replication, but …

Encapsulated cell-based therapies for solid tumors have shown promising results in pre-
clinical settings. However, the inability to culture encapsulated therapeutic cells prior to their …

Abstract Purpose of Review Computational and mathematical modeling have become a
critical part of understanding in-host infectious disease dynamics and predicting effective …

Gastrointestinal tumors are the most common cancers with the highest morbidity and
mortality worldwide. Surgery accompanied by chemotherapy, radiotherapy and targeted …

Agent-based models (ABMs) are readily used to capture the stochasticity in tumour
evolution; however, these models are often challenging to validate with experimental …

The primary goal of drug developers is to establish efficient and effective therapeutic
protocols. Multifactorial pathologies, including dynamical diseases and complex disorders …