GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted
adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral …

Feline coronavirus (FCoV) is a ubiquitous RNA virus of cats, which is transmitted faeco-
orally. In these guidelines, the European Advisory Board on Cat Diseases (ABCD) presents …

Background Nucleoside analog GS‐441524 is effective in treating cats with feline infectious
peritonitis (FIP). Investigation into the use of parent nucleotide analog remdesivir (GS‐5734) …

Objectives Feline infectious peritonitis (FIP), a common disease in cats caused by feline
coronavirus (FCoV), is usually fatal once clinical signs appear. Successful treatment of FIP …

Objectives Feline infectious peritonitis (FIP) is a serious disease that arises due to feline
coronavirus infection. The nucleoside analogues remdesivir and GS-441524 can be …

Feline infectious peritonitis (FIP) is a fatal disease of cats that currently lacks licensed and
affordable vaccines or antiviral therapeutics. The disease has a spectrum of clinical …

While clinical studies on acute phase proteins (APPs) have significantly increased in the last
decade, and most commercial labs are now offering major APPs in their biochemical …

As previously demonstrated by our research group, the oral multicomponent drug
Xraphconn® containing GS-441524 was effective at curing otherwise fatal feline infectious …

After an incubation period of weeks to months, up to 14% of cats infected with feline
coronavirus (FCoV) develop feline infectious peritonitis (FIP): a potentially lethal …

Coronaviruses are a diverse subfamily of viruses containing pathogens of humans and
animals. This subfamily of viruses replicates their RNA genomes using a core polymerase …