Regulation of ligands for the NKG2D activating receptor
NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected …
as a major recognition receptor for detection and elimination of transformed and infected …
Metalloproteinases and their natural inhibitors in inflammation and immunity
R Khokha, A Murthy, A Weiss - Nature Reviews Immunology, 2013 - nature.com
Over the past 50 years, steady growth in the field of metalloproteinase biology has shown
that the degradation of extracellular matrix components represents only a fraction of the …
that the degradation of extracellular matrix components represents only a fraction of the …
Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity
MICA and MICB are expressed by many human cancers as a result of cellular stress, and
can tag cells for elimination by cytotoxic lymphocytes through natural killer group 2D …
can tag cells for elimination by cytotoxic lymphocytes through natural killer group 2D …
NKG2D and its ligands:“one for all, all for one”
The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …
Leveraging NKG2D ligands in immuno-oncology
Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …
new avenues towards the development of novel assets to achieve durable immune control …
ADAM17: a molecular switch to control inflammation and tissue regeneration
J Scheller, A Chalaris, C Garbers, S Rose-John - Trends in immunology, 2011 - cell.com
A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-α
converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface …
converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface …
Overcoming resistance to natural killer cell based immunotherapies for solid tumors
G Nayyar, Y Chu, MS Cairo - Frontiers in oncology, 2019 - frontiersin.org
Despite advances in the diagnostic and therapeutic modalities, the prognosis of several
solid tumor malignancies remains poor. Different factors associated with solid tumors …
solid tumor malignancies remains poor. Different factors associated with solid tumors …
Effect of NKG2D ligand expression on host immune responses
M Champsaur, LL Lanier - Immunological reviews, 2010 - Wiley Online Library
Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …
Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens
RW Childs, M Carlsten - Nature reviews Drug discovery, 2015 - nature.com
Scientific insights into the human immune system have recently led to unprecedented
breakthroughs in immunotherapy. In the twenty-first century, drugs and cell-based therapies …
breakthroughs in immunotherapy. In the twenty-first century, drugs and cell-based therapies …
Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA* 008 that is shed by tumor cells in exosomes
O Ashiru, P Boutet, L Fernández-Messina… - Cancer research, 2010 - AACR
The MHC class I–related chain (MIC) A and MICB ligands for the activating receptor NKG2D
can be shed from tumor cells, and the presence of these soluble molecules in sera is related …
can be shed from tumor cells, and the presence of these soluble molecules in sera is related …