Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview
F Brosseron, M Krauthausen, M Kummer… - Molecular …, 2014 - Springer
This article gives a comprehensive overview of cytokine and other inflammation associated
protein levels in plasma, serum and cerebrospinal fluid (CSF) of patients with Alzheimer's …
protein levels in plasma, serum and cerebrospinal fluid (CSF) of patients with Alzheimer's …
ApoE4 accelerates early seeding of amyloid pathology
Accumulation and aggregation of amyloid-β (Aβ) in the brain is an initiating step in the
pathogenesis of Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (apoE) gene is …
pathogenesis of Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (apoE) gene is …
Apolipoprotein E in Alzheimer's disease: an update
JT Yu, L Tan, J Hardy - Annual review of neuroscience, 2014 - annualreviews.org
The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …
APOE and Alzheimer's Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer's Pathogenesis
MS Uddin, MT Kabir, A Al Mamun… - Molecular …, 2019 - Springer
Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two
hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau …
hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau …
Apolipoprotein E as a therapeutic target in Alzheimer's disease: a review of basic research and clinical evidence
Y Yamazaki, MM Painter, G Bu, T Kanekiyo - CNS drugs, 2016 - Springer
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes
progressive cognitive decline. The majority of AD cases are sporadic and late-onset (> 65 …
progressive cognitive decline. The majority of AD cases are sporadic and late-onset (> 65 …
Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model
ApoE4 is a major genetic risk determinant for Alzheimer's disease (AD) and drives its
pathogenesis via Aβ-dependent and-independent pathways. C/EBPβ, a proinflammatory …
pathogenesis via Aβ-dependent and-independent pathways. C/EBPβ, a proinflammatory …
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease
ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ)
metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its …
metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its …
Obesity and sex interact in the regulation of Alzheimer's disease
VA Moser, CJ Pike - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, for which a number
of genetic, environmental, and lifestyle risk factors have been identified. A significant …
of genetic, environmental, and lifestyle risk factors have been identified. A significant …
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer's
disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is …
disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is …