Multifaceted role of neuropilins in the immune system: potential targets for immunotherapy
Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …
Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance
Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system
development by regulating angiogenesis and axon guidance cues. Several published …
development by regulating angiogenesis and axon guidance cues. Several published …
Neuropilins in the context of tumor vasculature
S Niland, JA Eble - International journal of molecular sciences, 2019 - mdpi.com
Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors
originally identified by the binding of semaphorin and vascular endothelial growth factor …
originally identified by the binding of semaphorin and vascular endothelial growth factor …
EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression
Z Feng, L Zheng, T Yao, S Tao, X Wei, Z Zheng… - Cell Death & …, 2021 - nature.com
Emerging evidence indicates that circRNAs are broadly expressed in osteosarcoma (OS)
cells and play a crucial role in OS progression. Recently, cancer-specific circRNA …
cells and play a crucial role in OS progression. Recently, cancer-specific circRNA …
FGA controls VEGFA secretion to promote angiogenesis by activating the VEGFR2-FAK signalling pathway
H Li, E Cai, H Cheng, X Ye, R Ma, H Zhu… - Frontiers in …, 2022 - frontiersin.org
Background Our previous work revealed the high expression of fibrinogen alpha chain
(FGA) in patients with endometriosis (EM) and that it could promote the migration and …
(FGA) in patients with endometriosis (EM) and that it could promote the migration and …
LncRNA XIST facilitates proliferation and epithelial–mesenchymal transition of colorectal cancer cells through targeting miR‐486‐5p and promoting neuropilin‐2
A Liu, L Liu, H Lu - Journal of cellular physiology, 2019 - Wiley Online Library
This study was designed to acertain whether the long noncoding RNA (lncRNA) X‐inactive
specific transcript (XIST)/miR‐486‐5p/neuropilin‐2 (NRP‐2) pathway might promote the …
specific transcript (XIST)/miR‐486‐5p/neuropilin‐2 (NRP‐2) pathway might promote the …
NRP-2 in tumor lymphangiogenesis and lymphatic metastasis
J Wang, Y Huang, J Zhang, B Xing, W Xuan, H Wang… - Cancer letters, 2018 - Elsevier
Abstract Neuropilin-2 (NRP-2) not only functions as a receptor for semaphorins, a family of
neural axon guidance factors, but also interacts with VEGFs, a family of vascular endothelial …
neural axon guidance factors, but also interacts with VEGFs, a family of vascular endothelial …
Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma
Y Zhang, YS Zvi, B Batko, N Zaphiros, EF O'Donnell… - Scientific reports, 2018 - nature.com
Osteosarcoma (OS), the most common primary cancer of bone, exhibits a high propensity for
local invasion and distant metastasis. This study sought to elucidate the role of S phase …
local invasion and distant metastasis. This study sought to elucidate the role of S phase …
NRP2 promotes atherosclerosis by upregulating PARP1 expression and enhancing low shear stress‐induced endothelial cell apoptosis
S Luo, F Wang, S Chen, A Chen, Z Wang… - The FASEB …, 2022 - Wiley Online Library
Atherosclerosis‐related cardiovascular diseases are leading causes of mortality worldwide,
characterized by the development of endothelial cell dysfunction, increased oxidized low …
characterized by the development of endothelial cell dysfunction, increased oxidized low …
miR-486-5p attenuates tumor growth and lymphangiogenesis by targeting neuropilin-2 in colorectal carcinoma
C Liu, M Li, Y Hu, N Shi, H Yu, H Liu… - OncoTargets and …, 2016 - Taylor & Francis
Increasing evidence suggests that microRNAs are associated with many important biologic
processes in carcinogenesis. Despite ample research revealing the dysregualtion of miR …
processes in carcinogenesis. Despite ample research revealing the dysregualtion of miR …