Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Antibodies as ideal therapeutic and diagnostic molecules are among the top-selling drugs
providing considerable efficacy in disease treatment, especially in cancer therapy …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

The endothelial cells that compose the vascular system in the body display a wide range of
mechanotransductive behaviors and responses to biomechanical stimuli, which act in …

Hypoxia-induced pulmonary hypertension (PH) is one of the most common and deadliest
forms of PH. Fibroblast growth factor receptors 1 and 2 (FGFR1/2) are elevated in patients …

Cancer‐associated fibroblasts (CAFs) are known to promote tumourigenesis through
various mechanisms. Fibroblast growth factor (FGF)/FGF receptor (FGFR)‐dependent lung …

Vasculogenic mimicry (VM) is a mechanism whereby cancer cells form microvascular
structures similar to three-dimensional channels to provide nutrients and oxygen to tumors …

Blood brain barrier (BBB) conserves unique regulatory system to maintain barrier tightness
while allowing adequate transport between neurovascular units. This mechanism possess a …

The presence of an immature tumor vascular network contributes to cancer dissemination
and the development of resistance to therapies. Strategies to normalize the tumor …

Alveologenesis is an essential developmental process that increases the surface area of the
lung through the formation of septal ridges. In the mouse, septation occurs postnatally and is …