Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …

Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …

Glioblastoma is the most common and lethal primary malignant brain tumor in adults.
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

WNT/β-catenin signaling is involved in many physiological processes. Its implication in
embryonic development, cell migration, and polarization has been shown. Nevertheless …

Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of
stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase …

Transposable elements (TEs) are abundant in the human genome, and some are capable of
generating new insertions through RNA intermediates. In cancer, the disruption of cellular …

Tissues with defined cellular hierarchies in development and homeostasis give rise to
tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and …

Eighty percent of malignant tumors that develop in the central nervous system are malignant
gliomas, which are essentially incurable. Here, we discuss how recent sequencing studies …