Protein lysine methylation is a critical and dynamic post-translational modification that can
regulate protein stability and function. This post-translational modification is regulated by …

Identifying the mechanisms underlying the regulation of immune checkpoint molecules and
the therapeutic impact of targeting them in cancer is critical. Here we show that high …

Simple Summary The protein methyltransferase SETD7 is essential for epigenetic regulation
through methylation of histone H3 and non-histone proteins, including cell cycle, apoptosis …

The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master
transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to …

Glioma is a brain cancer characterized by strong invasiveness with limited treatment options
and poor prognosis. Recently, dysregulation of long non-coding RNAs (lncRNAs) has …

High levels of mitochondrial reactive oxygen species (mROS) are linked to cancer
development, which is tightly controlled by the electron transport chain (ETC). However, the …

Ferroptosis is a type of programmed cell death caused by disruption of redox homeostasis
and is closely linked to amino acid metabolism. Yin Yang 2 (YY2) and its homolog Yin Yang …

High-throughput chromosome conformation capture assays, such as Hi-C, have shown that
the genome is organized into organizational units such as topologically associating domains …

Down syndrome (DS) is the most common chromosomal disorder and a major cause of
intellectual disability. The genetic etiology of DS is the extra copy of chromosome 21 …

Previously, we have shown hyperhomocysteinemia (HHcy) to have a detrimental effect on
bone remodeling, which is associated with osteoporosis. During transsulfuration, Hcy is …