Childhood IgA vasculitis (Henoch Schonlein purpura)—advances and knowledge gaps

L Oni, S Sampath - Frontiers in pediatrics, 2019 - frontiersin.org
Immunoglobulin A vasculitis (IgAV; formerly Henoch Schonlein Purpura) is the most
common form of childhood vasculitis. It can occur in any age and peaks around 4–6 years …

KDIGO 2021 clinical practice guideline for the management of glomerular diseases

BH Rovin, SG Adler, J Barratt, F Bridoux… - Kidney …, 2021 - kidney-international.org
Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

IgA vasculitis with nephritis: update of pathogenesis with clinical implications

MC Hastings, DV Rizk, K Kiryluk, R Nelson, RS Zahr… - Pediatric …, 2022 - Springer
IgA vasculitis with nephritis (IgAVN) shares many pathogenetic features with IgA
nephropathy (IgAN). The purpose of this review is to describe our current understanding of …

[HTML][HTML] A systematic literature review of the epidemiology, health-related quality of life impact, and economic burden of immunoglobulin A nephropathy

CS Kwon, P Daniele, A Forsythe… - Journal of Health …, 2021 - ncbi.nlm.nih.gov
Introduction: This systematic literature review analyzed published evidence on IgA
nephropathy (IgAN), focusing on US epidemiology, health-related quality of life (HRQoL) …

IgA vasculitis and IgA nephropathy: same disease?

E Pillebout - Journal of clinical medicine, 2021 - mdpi.com
Many authors suggested that IgA Vasculitis (IgAV) and IgA Nephropathy (IgAN) would be
two clinical manifestations of the same disease; in particular, that IgAV would be the …

IgA vasculitis nephritis in children and adults: one or different entities?

L Peruzzi, R Coppo - Pediatric Nephrology, 2021 - Springer
The clinical features of the kidney involvement in immunoglobulin A (IgA) vasculitis (IgAVN)
differ in children and adults for both clinical presentation and progression. IgAVN in children …

IgA vasculitis (Henoch–Schönlein purpura): refractory and relapsing disease course in the adult population

E Van de Perre, RB Jones… - Clinical Kidney Journal, 2021 - academic.oup.com
Background The disease course of adult immunoglobulin A (IgA) vasculitis (IgAV; Henoch–
Schönlein purpura) has not been well defined. Methods In a retrospective survey, we …

Sparsentan ameliorates glomerular hypercellularity and inflammatory-gene networks induced by IgA1-IgG immune complexes in a mouse model of IgA nephropathy

C Reily, Z Moldoveanu, T Pramparo… - American Journal …, 2024 - journals.physiology.org
IgA nephropathy (IgAN) is characterized by glomerular deposition of immune complexes
(ICs) consisting of IgA1 with O-glycans deficient in galactose (Gd-IgA1) and Gd-IgA1-specific …

Immunoglobulin A glycosylation and its role in disease

AL Hansen, C Reily, J Novak, MB Renfrow - Antibody Glycosylation, 2021 - Springer
Human IgA is comprised of two subclasses, IgA1 and IgA2. Monomeric IgA (mIgA),
polymeric IgA (pIgA), and secretory IgA (SIgA) are the main molecular forms of IgA. The …

Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children

X Zhong, J Ding - Pediatric Nephrology, 2023 - Springer
Abstract IgA nephropathy (IgAN) and IgA vasculitis-associated nephritis (IgAVN) are among
the most frequent childhood glomerular diseases and are characterized by significant …