Pancreatic lipase inhibitors: The road voyaged and successes
A Kumar, S Chauhan - Life Sciences, 2021 - Elsevier
Human pancreatic lipase (triacylglycerol acyl hydrolase EC3. 1.1. 3) is the most widely
studied member of the human lipase superfamily related to carboxyl esterase. It is secreted …
studied member of the human lipase superfamily related to carboxyl esterase. It is secreted …
[HTML][HTML] Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR)
AKD bin Ahmad Kamar, LJ Yin, CT Liang… - Medicine in Drug …, 2022 - Elsevier
Diabetes is a chronic medical condition due to the lack of insulin or ineffective use of insulin.
In recent years, diabetes has become one of the rapidly growing chronic diseases, and it …
In recent years, diabetes has become one of the rapidly growing chronic diseases, and it …
Gallotannins are uncompetitive inhibitors of pancreatic lipase activity
EN Moreno-Córdova, AA Arvizu-Flores… - Biophysical …, 2020 - Elsevier
Inhibition of pancreatic lipase (PL) is used to treat dyslipidemias and obesity. Phenolic
compounds are highly bioactive molecules that can inhibit various enzymes. Our aim was to …
compounds are highly bioactive molecules that can inhibit various enzymes. Our aim was to …
Berberine inhibited growth and migration of human colon cancer cell lines by increasing phosphatase and tensin and inhibiting aquaporins 1, 3 and 5 expressions
Introduction: Berberine is a natural isoquinoline alkaloid with anti-cancer properties.
Nevertheless, the underlying mechanism of its action in human colorectal cancer (CRC) has …
Nevertheless, the underlying mechanism of its action in human colorectal cancer (CRC) has …
Medicinal plants and natural products: More effective and safer pharmacological treatment for the management of obesity
Obesity is a major lifestyle disorder, and it is correlated with several ailments. The
prevalence of obesity has elevated over the years, and it has become a global health …
prevalence of obesity has elevated over the years, and it has become a global health …
Stephalagine, an alkaloid with pancreatic lipase inhibitory activity isolated from the fruit peel of Annona crassiflora Mart.
MN Pereira, AB Justino, MM Martins, LG Peixoto… - Industrial Crops and …, 2017 - Elsevier
Annona crassiflora Mart., a member of the Annonaceae family found in the Brazilian
Savannah, is acknowledged as a plant rich in a variety of isoquinoline alkaloids. The …
Savannah, is acknowledged as a plant rich in a variety of isoquinoline alkaloids. The …
Plant products and their inhibitory activity against pancreatic lipase
Imbalance in metabolism can lead to many health complications, and obesity is one of the
alarming ones in the new world. Modern lifestyle has reduced physical activity and …
alarming ones in the new world. Modern lifestyle has reduced physical activity and …
Use of simplified molecular input line entry system and molecular graph based descriptors in prediction and design of pancreatic lipase inhibitors
Aim: The inhibition of pancreatic lipase (PL) enzyme is the most explored strategy for the
treatment of obesity. The present study describes the development of quantitative structure …
treatment of obesity. The present study describes the development of quantitative structure …
Inhibitory kinetics and mechanism of pentacyclic triterpenoid from endophytic Colletotrichum gigasporum against pancreatic lipase
R Patil, S Patil, V Maheshwari, M Patil - International Journal of Biological …, 2021 - Elsevier
The burden of obesity is increasing all over the world. Except for Orlistat, no effective anti-
obesity drug is currently available. Therefore, a search for the new anti-obesity compound is …
obesity drug is currently available. Therefore, a search for the new anti-obesity compound is …
Antilipase and antiproliferative activities of novel fluoroquinolones and triazolofluoroquinolones
Fluoroquinolones (FQs) have been identified recently as potent inhibitors of pancreatic
lipase (PL). The aim of this study was to synthesize novel FQs and triazolofluoroquinolones …
lipase (PL). The aim of this study was to synthesize novel FQs and triazolofluoroquinolones …