Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents
several challenges for neuroscience. Recent advances in its genetic and developmental …

A decade ago, we hypothesized that drug addiction can be viewed as a transition from
voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by …

Prominent theories suggest that compulsive behaviors, characteristic of obsessive-
compulsive disorder and addiction, are driven by shared deficits in goal-directed control …

Anxiety disorders are the most common mental disorders and are often chronic and
disabling. Although exposure-based treatments are effective, a substantial number of …

Objective: Biomarkers are defined as anatomical, biochemical or physiological traits that are
specific to certain disorders or syndromes. The objective of this paper is to summarise the …

Translating advances in neuroscience into benefits for patients with mental illness presents
enormous challenges because it involves both the most complex organ, the brain, and its …

Behavioral and neural evidence reveal a prospective goal-directed decision process that
relies on mental simulation of the environment, and a retrospective habitual process that …

Background A recent hypothesis has suggested that core deficits in goal-directed behavior
in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We …

Computational psychiatry is a rapidly growing field attempting to translate advances in
computational neuroscience and machine learning into improved outcomes for patients …

Abstract Obsessive-Compulsive Disorder (OCD) is characterized by maladaptive patterns of
repetitive, inflexible cognition and behavior that suggest a lack of cognitive flexibility …