Association between vaccination status and mortality among intubated patients with COVID-19–related acute respiratory distress syndrome

E Grapsa, G Adamos, I Andrianopoulos… - JAMA network …, 2022 - jamanetwork.com
Importance Although vaccination substantially reduces the risk of severe COVID-19, it is yet
unknown whether vaccinated patients who develop COVID-19 and require invasive …

[PDF][PDF] COVID-19 Compared with Other Viral Diseases: Novelties, Progress, and Challenges.

L Wang, CA Alexander - Electronic Journal of General Medicine, 2021 - ejgm.co.uk
Accepted: 4 Aug. 2020 COVID-19 is a newly discovered, highly infectious disease and has
rapidly spread into at least 213 countries as a pandemic. This paper is a comprehensive …

Postoperative acute respiratory distress syndrome in randomized controlled trials

VG Giannakoulis, E Papoutsi, V Kaldis, A Tsirogianni… - Surgery, 2023 - Elsevier
Background Acute respiratory distress syndrome is a potentially fatal postoperative
complication. We aimed to estimate temporal trends of the representation of patients with …

Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts

NA Sathe, LR Zelnick, C Mikacenic, ED Morrell… - Critical Care, 2021 - Springer
Background Acute hypoxemic respiratory failure (HRF) is associated with high morbidity and
mortality, but its heterogeneity challenges the identification of effective therapies. Defining …

Rapidly improving acute respiratory distress syndrome in COVID-19: a multi-centre observational study

E Gavrielatou, K Vaporidi, V Tsolaki, N Tserlikakis… - Respiratory …, 2022 - Springer
Background Before the pandemic of coronavirus disease (COVID-19), rapidly improving
acute respiratory distress syndrome (ARDS), mostly defined by early extubation, had been …

Development and External Validation of Models to Predict Persistent Hypoxemic Respiratory Failure for Clinical Trial Enrichment

NA Sathe, LR Zelnick, ED Morrell… - Critical care …, 2024 - journals.lww.com
OBJECTIVES: Improving the efficiency of clinical trials in acute hypoxemic respiratory failure
(HRF) depends on enrichment strategies that minimize enrollment of patients who quickly …

Rapidly improving ARDS differs clinically and biologically from persistent ARDS

PL Valda Toro, A Willmore, NE Wu, KL Delucchi… - Critical Care, 2024 - Springer
Background Rapidly improving acute respiratory distress syndrome (RIARDS) is an
increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after …

Temporal trends of outcomes of neutropenic patients with ARDS enrolled in therapeutic clinical trials

DR Price, KL Hoffman, E Sanchez, AMK Choi… - Intensive care …, 2021 - Springer
Dear Editor, Outcomes of critically ill patients with neutropenia (including those with acute
respiratory distress syndrome (ARDS)) improve over time, as suggested by data from …

Prolonged mechanical ventilation in acute respiratory distress syndrome

I Andrianopoulos, VG Giannakoulis, E Papoutsi… - Shock, 2023 - journals.lww.com
Purpose Trajectory of acute respiratory distress syndrome (ARDS) spans from rapidly
improving cases to cases receiving prolonged mechanical ventilation (PMV). We attempted …

Innovation in Enrichment: Is Persistence Enough?

EJ Schenck, II Siempos - Critical Care Medicine, 2024 - journals.lww.com
Clinical trials targeting patients who receive mechanical ventilation often fail (1). There are
numerous causes of this failure, from unmodifiable patient characteristics resulting in poor …