Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

Highlights•The Caenorhabditis elegans motor circuit has a nearly complete connectome.•
Neurogenetic studies are unveiling a rich and complex set of signaling relationships …

In most mouse models of disease, the outward manifestation of a disorder can be measured
easily, can be assessed with a trivial test such as hind limb clasping, or can even be …

Controllable, precise, and stable rotational manipulation of model organisms is valuable in
many biomedical, bioengineering, and biophysics applications. We present an …

The emerging field of optogenetics allows for optical activation or inhibition of excitable cells.
In 2005, optogenetic proteins were expressed in the nematode Caenorhabditis elegans for …

Imaging living organisms at high spatial resolution requires effective and innocuous
immobilization. Long-term imaging places further demands on sample mounting with …

Alternative splicing is important for the development and function of the nervous system, but
little is known about the differences in alternative splicing between distinct types of neurons …

Ion channels are specialized multimeric proteins that underlie cell excitability. These
channels integrate with a variety of neuromuscular and biological functions. In nematodes …

The intrinsic oscillatory activity of central pattern generators underlies motor rhythm. We
review and discuss recent findings that address the origin of Caenorhabditis elegans motor …

Certain thermoreceptor neurons are sensitive to tiny thermal fluctuations (0.01° C or less)
and maintain their sensitivity across a wide range of ambient temperatures through a …