Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …

Osteoporosis (OP) is a chronic bone disease characterized by aberrant microstructure and
macrostructure of bone, leading to reduced bone mass and increased risk of fragile …

Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …

A growing body of evidence has suggested that circular RNAs (circRNAs) are crucial for the
regulation of gene expression and their dysregulation is implicated in several diseases …

Wnt is a major signaling pathway involved in multifaceted roles of various biological
processes. Bones are dynamic tissues which are able to remodel and maintain the tissue …

During bone marrow stromal cell (BMSC) differentiation, both Wnt signaling and the
development of a rigid cytoskeleton promote commitment to the osteoblastic over …

Epigenetic mechanisms control skeletal development and osteoblast differentiation.
Pharmacological inhibition of the histone 3 Lys-27 (H3K27) methyltransferase enhancer of …

This one-year double blind randomized control trial assessed the effects of nightly
melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7; MSDK) on bone mineral …

Bone-stimulatory therapeutics include bone morphogenetic proteins (eg BMP2), parathyroid
hormone, and antibody-based suppression of WNT antagonists. Inhibition of the epigenetic …