The importance of antimicrobial resistance in medical mycology

NAR Gow, C Johnson, J Berman, AT Coste… - Nature …, 2022 - nature.com
Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global
health care priority. Some analyses, including the O'Neill report, have predicted that deaths …

Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

The oral microbiota: community composition, influencing factors, pathogenesis, and interventions

X Li, Y Liu, X Yang, C Li, Z Song - Frontiers in microbiology, 2022 - frontiersin.org
The human oral cavity provides a habitat for oral microbial communities. The complexity of
its anatomical structure, its connectivity to the outside, and its moist environment contribute …

Drug resistance and tolerance in fungi

J Berman, DJ Krysan - Nature Reviews Microbiology, 2020 - nature.com
Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

[HTML][HTML] Resistance of Candida to azoles and echinocandins worldwide

KE Pristov, MA Ghannoum - Clinical Microbiology and Infection, 2019 - Elsevier
Background Recently there has been an increase in Candida infections worldwide. A
handful of species in the genus Candida are opportunistic pathogens and have been known …

Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation

NM Revie, KR Iyer, ME Maxson, J Zhang, S Yan… - Nature …, 2022 - nature.com
Fungal infections cause more than 1.5 million deaths annually. With an increase in immune-
deficient susceptible populations and the emergence of antifungal drug resistance, there is …

[HTML][HTML] Facilitators of adaptation and antifungal resistance mechanisms in clinically relevant fungi

MWJ Hokken, BJ Zwaan, WJG Melchers… - Fungal genetics and …, 2019 - Elsevier
Opportunistic fungal pathogens can cause a diverse range of diseases in humans. The
increasing rate of fungal infections caused by strains that are resistant to commonly used …

[HTML][HTML] What do we know about the biology of the emerging fungal pathogen of humans Candida auris?

GB Ruiz, A Lorenz - Microbiological Research, 2021 - Elsevier
Candida auris is a worrisome fungal pathogen of humans which emerged merely about a
decade ago. Ever since then the scientific community worked hard to understand clinically …

Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus Candida albicans

AT Nishimoto, C Sharma… - Journal of Antimicrobial …, 2020 - academic.oup.com
Candida albicans is an opportunistic yeast and the major human fungal pathogen in the
USA, as well as in many other regions of the world. Infections with C. albicans can range …

LncRNA DINOR is a virulence factor and global regulator of stress responses in Candida auris

J Gao, EWL Chow, H Wang, X Xu, C Cai, Y Song… - Nature …, 2021 - nature.com
The emergent fungal pathogen Candida auris exhibits high resistance to antifungal drugs
and environmental stresses, impeding treatment and decontamination,–. The fungal factors …