The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

RJ Grams, WL Santos, IR Scorei, A Abad-García… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Carbaboranes as pharmacophores: properties, synthesis, and application strategies

M Scholz, E Hey-Hawkins - Chemical Reviews, 2011 - ACS Publications
Medicinal chemistry is still clearly dominated by organic chemistry. Most of the marketed
drugs are purely organic molecules. The right-hand neighbors of carbon in the periodic …

Too persistent to give up: Aromaticity in boron clusters survives radical structural changes

J Poater, C Viñas, I Bennour, S Escayola… - Journal of the …, 2020 - ACS Publications
o-C2B10H12 isomerizes to m-C2B10H12 upon heating at 400° C. Deboronation in o-
C2B10H12 is a relatively easy process, whereas it is more difficult in m-C2B10H12. These …

Boron science

NS Hosmane - New technologies and applications, 2011 - api.taylorfrancis.com
What is boron? The question itself may not seem very significant to many people. Their
introduction to the word “boron” could come as the butt of a joke. Conan O'Brien made jokes …

Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds

F Issa, M Kassiou, LM Rendina - Chemical reviews, 2011 - ACS Publications
Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …

Nido‐Carboranes: Donors for Thermally Activated Delayed Fluorescence

NV Nghia, S Jana, S Sujith, JY Ryu… - Angewandte Chemie …, 2018 - Wiley Online Library
An approach to the design of nido‐carborane‐based luminescent compounds that can
exhibit thermally activated delayed fluorescence (TADF) is proposed. 7, 8‐Dicarba‐nido …

Water soluble organometallic small molecules as promising antibacterial agents: synthesis, physical–chemical properties and biological evaluation to tackle bacterial …

I Bennour, MN Ramos, M Nuez-Martínez… - Dalton …, 2022 - pubs.rsc.org
The Na [3, 3′-Fe (8-I-1, 2-C2B9H10) 2] and Na [2, 2′-M (1, 7-C2B9H11)](M= Co3+, Fe3+)
small molecules are synthesized and the X-ray structures of [(H3O)(H2O) 5][2, 2′-Co (1, 7 …

Facile and Mild Deboronation of o-Carboranes Using Cesium Fluoride

J Yoo, JW Hwang, Y Do - Inorganic Chemistry, 2001 - ACS Publications
Facile and Mild Deboronation of o-Carboranes Using Cesium Fluoride | Inorganic Chemistry
ACS ACS Publications C&EN CAS Find my institution Log In Inorganic Chemistry ACS …

Iridium-Catalyzed Cage B(4)-Amidation Reaction of o-Carboranes with Dioxazolones: Selective Synthesis of Amidated o-Carboranes and Amidated and Methoxycarbonylated …

GU Han, Y Baek, K Lee, S Shin, H Chan Noh… - Organic …, 2020 - ACS Publications
Described is the Ir-catalyzed cage B (4)-amidation of o-carboranes with dioxazolones by
carboxylic acid-assisted B (4)–H bond activation under extremely mild conditions, affording …

Metal promoted charge and hapticities of phosphines: The uniqueness of carboranylphosphines

AR Popescu, F Teixidor, C Vinas - Coordination Chemistry Reviews, 2014 - Elsevier
The accurate selection of a ligand for a metal-catalyzed homogeneous reaction can be as
decisive as the selection of the metal. Incorporating a carborane cage as a backbone to …