Disease modification in inflammatory skin disorders: opportunities and challenges
T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …
Cellular and molecular immunologic mechanisms in patients with atopic dermatitis
T Werfel, JP Allam, T Biedermann, K Eyerich… - Journal of allergy and …, 2016 - Elsevier
Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases of
the atopic diathesis. Recent evidence supports the concept that AD can also recognize other …
the atopic diathesis. Recent evidence supports the concept that AD can also recognize other …
[HTML][HTML] Atopic dermatitis is an IL-13–dominant disease with greater molecular heterogeneity compared to psoriasis
LC Tsoi, E Rodriguez, F Degenhardt, H Baurecht… - Journal of Investigative …, 2019 - Elsevier
Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper
understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic …
understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic …
The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization
Background Atopic dermatitis (AD) shows very high prevalence in Asia, with a large unmet
need for effective therapeutics. Direct comparisons between European American (EA) and …
need for effective therapeutics. Direct comparisons between European American (EA) and …
Pathophysiology of psoriasis: A review
K Yamanaka, O Yamamoto… - The Journal of …, 2021 - Wiley Online Library
Psoriasis is a complex chronic inflammatory skin disease caused by the dynamic interplay
between multiple genetic risk foci, environmental risk factors, and excessive immunological …
between multiple genetic risk foci, environmental risk factors, and excessive immunological …
[HTML][HTML] Atopic Dermatitis in Children and Adults: Diagnosis and Treatment
A Wollenberg, T Werfel, J Ring, H Ott… - Deutsches Ärzteblatt …, 2023 - ncbi.nlm.nih.gov
Background Atopic dermatitis is a common, chronically recurring inflammatory skin disease.
It gives rise to a high disease burden and is of major importance in social medicine. Methods …
It gives rise to a high disease burden and is of major importance in social medicine. Methods …
Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
CT Weaver, CO Elson, LA Fouser… - Annual Review of …, 2013 - annualreviews.org
The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …
Immunology of atopic eczema: overcoming the T h1/T h2 paradigm
K Eyerich, N Novak - Allergy, 2013 - Wiley Online Library
Atopic eczema (AE) is a challenge for modern medicine, because it is prevalent, severely
affects quality of life of patients and their families, and causes high socioeconomic costs. The …
affects quality of life of patients and their families, and causes high socioeconomic costs. The …
Overlapping features of psoriasis and atopic dermatitis: from genetics to immunopathogenesis to phenotypes
YC Tsai, TF Tsai - International Journal of Molecular Sciences, 2022 - mdpi.com
Psoriasis (PSO) and atopic dermatitis (AD) were once considered to be mutually exclusive
diseases, but gradually regarded as a spectrum of disease. Shared genetic loci of both …
diseases, but gradually regarded as a spectrum of disease. Shared genetic loci of both …