Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis

T Werfel, JP Allam, T Biedermann, K Eyerich… - Journal of allergy and …, 2016 - Elsevier
Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases of
the atopic diathesis. Recent evidence supports the concept that AD can also recognize other …

[HTML][HTML] Atopic dermatitis is an IL-13–dominant disease with greater molecular heterogeneity compared to psoriasis

LC Tsoi, E Rodriguez, F Degenhardt, H Baurecht… - Journal of Investigative …, 2019 - Elsevier
Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper
understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic …

The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization

S Noda, M Suárez-Fariñas, B Ungar, SJ Kim… - Journal of Allergy and …, 2015 - Elsevier
Background Atopic dermatitis (AD) shows very high prevalence in Asia, with a large unmet
need for effective therapeutics. Direct comparisons between European American (EA) and …

Pathophysiology of psoriasis: A review

K Yamanaka, O Yamamoto… - The Journal of …, 2021 - Wiley Online Library
Psoriasis is a complex chronic inflammatory skin disease caused by the dynamic interplay
between multiple genetic risk foci, environmental risk factors, and excessive immunological …

[HTML][HTML] Atopic Dermatitis in Children and Adults: Diagnosis and Treatment

A Wollenberg, T Werfel, J Ring, H Ott… - Deutsches Ärzteblatt …, 2023 - ncbi.nlm.nih.gov
Background Atopic dermatitis is a common, chronically recurring inflammatory skin disease.
It gives rise to a high disease burden and is of major importance in social medicine. Methods …

Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets

L Fania, G Moretta, F Antonelli, E Scala… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …

The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin

CT Weaver, CO Elson, LA Fouser… - Annual Review of …, 2013 - annualreviews.org
The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding
of the pathogenetic basis of an increasing number of chronic immune-mediated diseases …

Immunology of atopic eczema: overcoming the T h1/T h2 paradigm

K Eyerich, N Novak - Allergy, 2013 - Wiley Online Library
Atopic eczema (AE) is a challenge for modern medicine, because it is prevalent, severely
affects quality of life of patients and their families, and causes high socioeconomic costs. The …

Overlapping features of psoriasis and atopic dermatitis: from genetics to immunopathogenesis to phenotypes

YC Tsai, TF Tsai - International Journal of Molecular Sciences, 2022 - mdpi.com
Psoriasis (PSO) and atopic dermatitis (AD) were once considered to be mutually exclusive
diseases, but gradually regarded as a spectrum of disease. Shared genetic loci of both …