Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It
constitutes a key element in the dissemination of antibiotic resistance and virulence genes to …

Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-
negative and gram-positive bacteria and in some archaea. These systems transport a …

Genetic exchange by conjugation is responsible for the spread of resistance, virulence, and
social traits among prokaryotes. Recent works unraveled the functioning of the underlying …

Mycobacterium tuberculosis and Staphylococcus aureus secrete virulence factors via type
VII protein secretion (T7S), a system that intriguingly requires all of its secretion substrates …

Antibiotic resistance has become one of the most challenging problems in health care.
Bacteria conjugation is one of the main mechanisms whereby bacteria become resistant to …

Pilus biogenesis and substrate transport by type IV secretion systems require energy, which
is provided by three molecular motors localized at the base of the secretion channel. One of …

Bacterial conjugation is the main mechanism for the dissemination of antibiotic resistance
genes. A single DNA strand of the conjugative plasmid is transferred across bacterial …

VirB4 proteins are ATPases essential for pilus biogenesis and protein transport in type IV
secretion systems. These proteins contain a motor domain that shares structural similarities …

Bacterial conjugation is a form of type IV secretion that transports protein and DNA to
recipient cells. Specific bacteriophage exploit the conjugative pili and cell envelope …

Bacterial conjugation is the main mechanism for horizontal gene transfer, conferring
plasticity to the genome repertoire. This process is also the major instrument for the …