The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …

Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in
myeloid lineage cells in which it acts to suppress proinflammatory cytokines following …

Failure to efficiently clear apoptotic cells is linked to defects in development and the onset of
autoimmunity. Complement component C1q is required for efficient engulfment of apoptotic …

Abstract Introduction Mer and Tyro3 are receptor tyrosine kinases important for the
phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family …

Abstract The TAM receptors—TYRO3, AXL, MERTK—are pleiotropically expressed
receptors in both healthy and diseased tissue. A complex of the ligands Protein S (PROS1) …

Objective—Scavenger receptor BI (SR-BI) is a high-density lipoprotein (HDL) receptor.
Recent studies revealed that SR-BI protects against sepsis via modulating innate immunity …

Background The mechanisms involved in the pathogenesis of autoimmune disorders,
including systemic lupus erythematosus (SLE), have not been fully elucidated. Some of …

Rheumatoid Arthritis (RA) is the most common chronic inflammatory autoimmune disease
involving joints. Among several pathogenic mechanisms, the impairment of homeostatic …

Tumor-infiltrating myeloid cells are a key component of the immune infiltrate often correlated
with a poor prognosis due to their capacities to sustain an immunosuppressive environment …