Notch signaling is a conserved system of communication between adjacent cells,
influencing numerous cell fate decisions in the development of multicellular organisms …

The development of multicellular organisms is controlled by highly dynamic molecular and
cellular processes organized in spatially restricted patterns. Recent advances in …

Cells receive enormous amounts of information from their environment. How they act on this
information—by migrating, expressing genes, or relaying signals to other cells—comprises …

Notch signalling controls many key cellular processes which differ according to the context
where the pathway is deployed due to the transcriptional activation of specific sets of genes …

The way in which interactions between mechanics and biochemistry lead to the emergence
of complex cell and tissue organization is an old question that has recently attracted …

Technological advances have driven many recent advances in developmental biology. Light
sheet imaging can reveal single-cell dynamics in living three-dimensional tissues, whereas …

YAP, an effector of the Hippo signalling pathway, promotes organ growth and regeneration.
Prolonged YAP activation results in uncontrolled proliferation and cancer. Therefore …

Deciphering gene function requires the ability to control gene expression in space and time.
Binary systems such as the Gal4/UAS provide a powerful means to modulate gene …

Cell biology is moving from observing molecules to controlling them in real time, a critical
step towards a mechanistic understanding of how cells work. Initially developed from light …

Optogenetics utilizes photosensitive proteins to manipulate the localization and interaction
of molecules in living cells. Because light can be rapidly switched and conveniently confined …