A review on human orf: a neglected viral zoonosis

T Kassa - Research and Reports in Tropical Medicine, 2021 - Taylor & Francis
Orf virus (ORFV) is the etiologic agent of Orf or ecthyma contagiosum in humans but
primarily affects different domestic and wild animals. The disease mostly affects sheep …

Recent advances in diagnostic approaches for orf virus

F Pang, Q Long - Applied Microbiology and Biotechnology, 2023 - Springer
Orf virus (ORFV), the prototype species of the Parapoxvirus genus, is an important zoonotic
virus, causing great economic losses in livestock production. At present, there are no …

Immunomodulatory strategies for parapoxvirus: current status and future approaches for the development of vaccines against Orf virus infection

AM Bukar, FFA Jesse, CAC Abdullah, MM Noordin… - Vaccines, 2021 - mdpi.com
Orf virus (ORFV), the prototype species of the parapoxvirus genus, is the causative agent of
contagious ecthyma, an extremely devastating skin disease of sheep, goats, and humans …

Human Orf with Immune-mediated reactions: a systematic review

L Rossi, G Tiecco, M Venturini, F Castelli… - Microorganisms, 2023 - mdpi.com
Background: Orf is a highly contagious zoonosis caused by Orf virus (ORFV), which is
endemic in sheep and goats worldwide. Human Orf is usually a self-limiting disease, but …

Designing a multi-epitope subunit vaccine against Orf virus using molecular docking and molecular dynamics

F Pang, Q Long, S Liang - Virulence, 2024 - Taylor & Francis
Orf virus (ORFV) is an acute contact, epitheliotropic, zoonotic, and double-stranded DNA
virus that causes significant economic losses in the livestock industry. The objective of this …

[HTML][HTML] Human infection with orf virus and description of its whole genome, France, 2017

J Andreani, J Fongue, JYB Khalil, L David… - Emerging infectious …, 2019 - ncbi.nlm.nih.gov
Zoonotic transmission of parapoxvirus from animals to humans has been reported; clinical
manifestations are skin lesions on the fingers and hands after contact with infected animals …

Orf virus DNA prime-protein boost strategy is superior to adenovirus-based vaccination in mice and sheep

Y Wang, S Sun, K Zhao, L Du, X Wang, W He… - Frontiers in …, 2023 - frontiersin.org
Contagious ecthyma (Orf), an acute and highly contagious zoonosis, is prevalent worldwide.
Orf is caused by Orf virus (ORFV), which mainly infects sheep/goats and humans. Therefore …

Genistein is effective in inhibiting Orf virus infection in vitro by targeting viral RNA polymerase subunit RPO30 protein

P Lv, Z Fang, J Guan, L Lv, M Xu, X Liu, Z Li… - Frontiers in …, 2024 - frontiersin.org
Orf virus (ORFV), a typical member of the genus Parapoxvirus, Poxvirus family, causes a
contagious pustular dermatitis in sheep, goats, and humans. Poxviruses encode a …

Stability studies for the identification of critical process parameters for a pharmaceutical production of the Orf virus

F Eilts, JJ Labisch, S Orbay, YMJ Harsy, M Steger… - Vaccine, 2023 - Elsevier
A promising new vaccine platform is based on the Orf virus, a viral vector of the genus
Parapoxvirus, which is currently being tested in phase I clinical trials. The application as a …

Contagious ecthyma: how serious is the disease worldwide?

Z Lawan, JA Bala, AM Bukar… - Animal Health …, 2021 - cambridge.org
Contagious ecthyma (CE) is an infectious disease of small ruminants caused by a
parapoxvirus of family Poxviridae subfamily Chordopoxvirinae. The disease is obviously …