Owing to its ability to depict the pathologic features of multiple sclerosis (MS) in exquisite
detail, conventional magnetic resonance (MR) imaging has become an established tool in …

The secondary progressive phase of multiple sclerosis (MS), which is characterised by a
steady accrual of fixed disability after an initial relapsing remitting course, is not clearly …

Damage to the myelin sheath and the neuroaxonal unit is a cardinal feature of multiple
sclerosis; however, a detailed characterization of the interaction between myelin and axon …

Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …

Objective: This study explores default-mode network (DMN) abnormalities in patients with
secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) and …

Objective: To assess cortical gray matter (GM) changes in MS and establish their relevance
to clinical disability and to inflammatory changes of white matter (WM) in patients with the …

BACKGROUND AND PURPOSE: Cortical lesions constitute a substantial part of the total
lesion load in multiple sclerosis (MS) brain. They have been related to neuropsychological …

Abstract As Norman Geschwind asserted in 1965, syndromes resulting from white matter
lesions could produce deficits in higher-order functions and “disconnexion” or the …

Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of
demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded …

The aim of our study is to evaluate the extent and distribution of grey matter demyelinating
lesions in multiple sclerosis (MS), addressing also neuronal loss and synaptic loss. Whole …