Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks
by catalyzing the substitution of the 2′ OH-group of a ribonucleotide with a hydrogen by a …

Ribonucleotide reductase (RNR) is a key enzyme that mediates the synthesis of
deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell. This …

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that
causes diarrheal disease in humans and animals. During salmonellosis, S. Typhimurium …

Incorporation of metallocofactors essential for the activity of many enyzmes is a major
mechanism of posttranslational modification. The cellular machinery required for these …

Staphylococcus aureus is a gram-positive facultative aerobe that can grow in the absence of
oxygen by fermentation or by using an alternative electron acceptor. To investigate the …

Nitric oxide (NO) is an intermediate of the respiratory pathway known as denitrification, and
is a by-product of anaerobic nitrite respiration in the enteric Bacteria. Pathogens are also …

Understanding how cells dynamically adapt to their environment is a primary focus of
biology research. Temporal information about cellular behavior is often limited by both small …

How cells ensure correct metallation of a given protein and whether a degree of promiscuity
in metal binding has evolved are largely unanswered questions. In a classic case, iron-and …

Nitric oxide produced by activated macrophages plays a key role as one of the immune
system's weapons against pathogens. Because the lifetime of nitric oxide is short in aerobic …

In recent years we have studied the relationship between strain genotypes and patient
phenotypes in group A Streptococcus (GAS), a model human bacterial pathogen that causes …