Fibrinogen is a large glycoprotein, synthesized primarily in the liver. With a normal plasma
concentration of 1.5–3.5 g/L, fibrinogen is the most abundant blood coagulation factor. The …

Fibrin is a promising natural polymer that is widely used for diverse applications, such as
hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite …

Although much has been established concerning the overall structure and function of
fibrinogen, much less has been known about its two αC regions, each consisting of an αC …

Polymeric fibrin displays unique structural and biomechanical properties that contribute to its
essential role of generating blood clots that stem bleeds. The aim of this review is to discuss …

Objective: GPVI (glycoprotein VI) is a key molecular player in collagen-induced platelet
signaling and aggregation. Recent evidence indicates that it also plays important role in …

Traffic accidents, falls, and many other events may cause traumatic spinal cord injuries
(SCIs), resulting in nerve cells and extracellular matrix loss in the spinal cord, along with …

Fibrinogen nanofibers hold great potential for applications in wound healing and
personalized regenerative medicine due to their ability to mimic the native blood clot …

The deformation mechanism of fibrin fibers has been a long-standing challenge to uncover
due to the fiber's complex structure and mechanical behaviors. In this paper, a …

Fibrinogen is essential for blood coagulation. The C-terminus of the fibrinogen α-chain (αC-
region) is composed of an αC-domain and αC-connector. Two recombinant fibrinogen …

The biomechanical properties of blood clots, which are dictated by their compositions and
micro-structures, play a critical role in determining their fates, ie, occlusion, persistency, or …