Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed,
and are present in the nucleus, cytosol, and mitochondria. Depending on the cellular …

Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in
transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell …

Mitophagy, which is a conserved cellular process for selectively removing damaged or
unwanted mitochondria, is critical for mitochondrial quality control and the maintenance of …

Ferroptosis is a new type of programmed cell death characterized by iron-dependent lipid
peroxidation. Ferroptosis inhibition is thought as a promising therapeutic strategy for a …

Background: Natural killer (NK) cell-based immunotherapy is clinically limited due to
insufficient tumor infiltration in solid tumors. We have previously found that the natural …

Background: Lung cancer has the highest mortality rate among cancers worldwide, with non-
small cell lung cancer (NSCLC) the most common type. Increasing evidence shows that …

Targeting macroautophagy/autophagy is a novel strategy in cancer immunotherapy. In the
present study, we showed that the natural product rocaglamide (RocA) enhanced natural …

Prohibitin (PHB) was originally isolated and characterized as an anti-proliferative gene in rat
liver. The evolutionarily conserved PHB gene encodes two human protein isoforms with …

In addition to mitochondrial DNA, mitochondrial double-stranded RNA (mtdsRNA) is
exported from mitochondria. However, specific channels for RNA transport have not been …

Over the last three decades, the scaffold proteins prohibitins-1 and-2 (PHB1/2) have
emerged as key signaling proteins regulating a myriad of signaling pathways in health and …