Abstract Background Clostridioides (Clostridium) difficile is an important pathogen of
healthcare-associated diarrhea, however, an increase in the occurrence of C. difficile …

In the last three decades, Clostridium difficile infection (CDI) has increased in incidence and
severity in many countries worldwide. The increase in CDI incidence has been particularly …

Abstract Background Efforts to prevent Clostridioides difficile infection continue to expand
across the health care spectrum in the United States. Whether these efforts are reducing the …

Clostridioides difficile Infection (Japanese Version) Page 1 Annals of Internal Medicine® In
the Clinic® Clostridioides difficile 感染症 Clostridioides difficile (以前はClostridium difficileと …

Background While antibiotics are life-saving drugs, their use is not without risk, including
adverse events and antibiotic resistance. The majority of US antibiotic prescriptions are …

Clostridioides difficile remains an important public health threat, globally. Since the
emergence of the hypervirulent strain, ribotype 027, new strains have been reported to …

Clostridium difficile infection (CDI) is a leading cause of healthcare-associated infections,
accounting for significant disease burden and mortality. The clinical spectrum of C. difficile …

Background The hospital environment is a source of pathogen transmission. The effect of
enhanced disinfection strategies on the hospital-wide incidence of infection has not been …

Pathogen whole-genome sequencing has become an important tool for understanding the
transmission and epidemiology of infectious diseases. It has improved our understanding of …

Antibiotic resistance is a major cause of treatment failure and leads to increased use of
broad-spectrum agents, which begets further resistance. This vicious cycle is epitomized by …