There is high variability in the response to antiepileptic treatment across people with
epilepsy. Genetic factors significantly contribute to such variability. Recent advances in the …

Many genetic variants in drug metabolizing enzymes and transporters have been shown to
be relevant for treating psychiatric disorders. Associations are strong enough to feature on …

Popular among students and clinicians for its easy-to-read, case-study format, Winter's Basic
Clinical Pharmacokinetics, 7th Edition, clarifies complex concepts to help you confidently …

Importance Precise estimation of a patient's drug metabolism capacity is important for
antiseizure dose personalization. Objective To quantify the differences in plasma …

Objective To ascertain possible determinants of carbamazepine (CBZ)–and oxcarbazepine
(OXC)–induced hyponatremia in a large cohort of people with epilepsy. Methods We …

The drug-metabolizing enzymes that contribute to the metabolism or bioactivation of a drug
play a crucial role in defining the absorption, distribution, metabolism, and excretion …

Pharmacogenomics can identify polymorphisms in genes involved in drug pharmacokinetics
and pharmacodynamics determining differences in efficacy and safety and causing inter …

Despite extensive research on epileptogenesis, there is still a need to investigate new
pathways and targeted therapeutic approaches in this complex process. Inflammation …

Epilepsy treatment is challenging due to heterogeneous syndromes, different seizure types
and higher inter-individual variability. Identification of genetic variants predicting drug …

The large number of different syndromes and seizure types together with an interindividual
variable response to antiepileptic drugs (AEDs) make the treatment of epilepsy challenging …