Human memory B cells
M Seifert, R Küppers - Leukemia, 2016 - nature.com
A key feature of the adaptive immune system is the generation of memory B and T cells and
long-lived plasma cells, providing protective immunity against recurring infectious agents …
long-lived plasma cells, providing protective immunity against recurring infectious agents …
[HTML][HTML] Sequencing the functional antibody repertoire—diagnostic and therapeutic discovery
WH Robinson - Nature Reviews Rheumatology, 2015 - nature.com
The development of high-throughput DNA sequencing technologies has enabled large-
scale characterization of functional antibody repertoires, a new method of understanding …
scale characterization of functional antibody repertoires, a new method of understanding …
Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires
Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …
sequence diversity and binding versatility have made Abs the primary class of …
Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires
Elucidating how antigen exposure and selection shape the human antibody repertoire is
fundamental to our understanding of B-cell immunity. We sequenced the paired heavy-and …
fundamental to our understanding of B-cell immunity. We sequenced the paired heavy-and …
The analysis of clonal expansions in normal and autoimmune B cell repertoires
U Hershberg, ET Luning Prak - … Transactions of the …, 2015 - royalsocietypublishing.org
Clones are the fundamental building blocks of immune repertoires. The number of different
clones relates to the diversity of the repertoire, whereas their size and sequence diversity …
clones relates to the diversity of the repertoire, whereas their size and sequence diversity …
[HTML][HTML] A public database of memory and naive B-cell receptor sequences
The vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition
of, and response to, a wide range of epitopes, but this diversity has also limited our …
of, and response to, a wide range of epitopes, but this diversity has also limited our …
Learning the high-dimensional immunogenomic features that predict public and private antibody repertoires
Recent studies have revealed that immune repertoires contain a substantial fraction of
public clones, which may be defined as Ab or TCR clonal sequences shared across …
public clones, which may be defined as Ab or TCR clonal sequences shared across …
[HTML][HTML] Reproducibility and reuse of adaptive immune receptor repertoire data
High-throughput sequencing (HTS) of immunoglobulin (B-cell receptor, antibody) and T-cell
receptor repertoires has increased dramatically since the technique was introduced in 2009 …
receptor repertoires has increased dramatically since the technique was introduced in 2009 …
[HTML][HTML] Sera antibody repertoire analyses reveal mechanisms of broad and pandemic strain neutralizing responses after human norovirus vaccination
Rapidly evolving RNA viruses, such as the GII. 4 strain of human norovirus (HuNoV), and
their vaccines elicit complex serological responses associated with previous exposure …
their vaccines elicit complex serological responses associated with previous exposure …
Characterization of T and B cell repertoire diversity in patients with RAG deficiency
Recombination-activating genes 1 and 2 (RAG1 and RAG2) play a critical role in T and B
cell development by initiating the recombination process that controls the expression of T …
cell development by initiating the recombination process that controls the expression of T …