Highlights•Thymoproteasome is expressed exclusively in cortical thymic epithelial cells.•
Thymoproteasome affects antigen processing of MHC-I-associated peptides.• …

Within the thymus, thymic epithelial cells (TECs) provide a dedicated niche for the selection
of functional T cells expressing a highly variable and self‐tolerant T‐cell receptor (TCR) …

Background: Ovarian cancer (OC) is one of the most malignant tumors in the female
reproductive system, with a poor prognosis. Various responses to treatments including …

Autophagy is primarily activated by cellular stress, such as starvation or mitochondrial
damage. However, stress-independent autophagy is activated by unclear mechanisms in …

The enzyme cyclic GMP-AMP synthase (cGAS) is a key sensor for detecting misplaced
double-stranded DNA (dsDNA) of genomic, mitochondrial, and microbial origin. It …

Background Aggrephagy is a critical compensatory mechanism for the elimination of
misfolded proteins resulting from stress and depends on the autolysosome degradation of …

The generation of a functional, self-tolerant T cell receptor (TCR) repertoire depends on
interactions between developing thymocytes and antigen-presenting thymic epithelial cells …

Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) that
results from autoantibodies against nicotinic acetylcholine receptors (nAchRs) at NMJs …

The immune system and autophagy share a functional relationship. Both innate and
adaptive immune responses involve autophagy and, depending on the disease's origin and …

Glycosylation is a critical post-translational modification that plays a pivotal role in several
biological processes, such as the immune response. Alterations in glycosylation can …