Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

The incidence of stroke plays the foremost role in the genesis of central neuropathic pain.
Central post-stroke pain (CPSP) is a central pain arising from a vascular lesion in the central …

In the past decade, prescriptions for opioid medicines have been exponentially increasing,
instigating opioid abuse as a global health crisis associated with high morbidity and …

In this research, the Au nanoparticle was synthesized using a biosynthesized strategy by
Mentha aquatic extract and characterized by Uv-vis spectroscopic method. The synthesized …

Study Design. Retrospective review of prospectively collected data. Objective. To analyze
the postoperative factors that led delayed discharge in patients who would have been …

In this work, we prepared a novel electrochemical sensor for the detection of tramadol based
on a UiO-66-NH2 metal–organic framework (UiO-66-NH2 MOF)/third-generation poly …

Pharmaceutical compounds and their metabolites are found in natural and wastewater.
However, investigation of their toxic effects on aquatic animals has been neglected …

In this study, the solubility of the tramadol hydrochloride (T-HCl) drug in supercritical carbon
dioxide (SC-CO 2) was determined for the first time. The experiments were conducted at …

The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our
ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The …

Selective hydrogenation of nitriles and alkynes is crucial considering the vast applications of
reduced products in industries and in the synthesis of bioactive compounds. Particularly, the …