Pseudomonas aeruginosa is a Gram-negative bacterial pathogen that is a common cause of
nosocomial infections, particularly pneumonia, infection in immunocompromised hosts, and …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

The most recent European guidelines and task force reports on hospital-acquired
pneumonia (HAP) and ventilator-associated pneumonia (VAP) were published almost 10 …

Background The β-lactamase inhibitor relebactam can restore imipenem activity against
imipenem-nonsusceptible gram-negative pathogens. We evaluated imipenem/relebactam …

Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

Severe or life threatening infections are common among patients in the intensive care unit
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …

In accordance with the recommendations of, amongst others, the Surviving Sepsis
Campaign and the recently published European treatment guidelines for hospital-acquired …

The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

Background Nosocomial pneumonia due to antimicrobial-resistant pathogens is associated
with high mortality. We assessed the efficacy and safety of the combination antibacterial …

The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs
worldwide constitute a problem of crisis dimensions. The root causes of this problem are …