The essential medicinal chemistry of curcumin: miniperspective

KM Nelson, JL Dahlin, J Bisson, J Graham… - Journal of medicinal …, 2017 - ACS Publications
Curcumin is a constituent (up to∼ 5%) of the traditional medicine known as turmeric. Interest
in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led …

[HTML][HTML] Free radicals, natural antioxidants, and their reaction mechanisms

SB Nimse, D Pal - RSC advances, 2015 - pubs.rsc.org
The normal biochemical reactions in our body, increased exposure to the environment, and
higher levels of dietary xenobiotic's result in the generation of reactive oxygen species …

[HTML][HTML] Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy

LD Dias, KC Blanco, IS Mfouo-Tynga, NM Inada… - … of Photochemistry and …, 2020 - Elsevier
Nowadays multi-drug resistant microorganisms is a serious public health problem
worldwide. To overcome it, new antimicrobial strategies have been developed. Among them …

[HTML][HTML] Formulation of more efficacious curcumin delivery systems using colloid science: enhanced solubility, stability, and bioavailability

B Zheng, DJ McClements - Molecules, 2020 - mdpi.com
Curcumin is a bioactive constituent isolated from turmeric that has historically been used as
a seasoning, pigment, and herbal medicine in food. Recently, it has become one of the most …

The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer

M Heger, RF van Golen, M Broekgaarden… - Pharmacological …, 2014 - ASPET
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Degradation of curcumin: from mechanism to biological implications

C Schneider, ON Gordon, RL Edwards… - Journal of agricultural …, 2015 - ACS Publications
Curcumin is the main bioactive ingredient in turmeric extract and widely consumed as part of
the spice mix curry or as a dietary supplement. Turmeric has a long history of therapeutic …

The mechanism (s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary …

A Hunyadi - Medicinal research reviews, 2019 - Wiley Online Library
Small molecule, dietary antioxidants exert a remarkably broad range of bioactivities, and
many of these can be explained by the influence of antioxidants on the redox homeostasis …

Mechanisms of phytonutrient modulation of cyclooxygenase-2 (COX-2) and inflammation related to cancer

SJ Desai, B Prickril, A Rasooly - Nutrition and cancer, 2018 - Taylor & Francis
The link between chronic inflammation and cancer involves cytokines and mediators of
inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism …

Curcumin: recent advances in the development of strategies to improve oral bioavailability

KZ Sanidad, E Sukamtoh, H Xiao… - Annual review of …, 2019 - annualreviews.org
Substantial human and preclinical studies have shown that curcumin, a dietary compound
from turmeric, has a variety of health-promoting effects including but not limited to …

[HTML][HTML] The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites

RL Edwards, PB Luis, PV Varuzza, AI Joseph… - Journal of Biological …, 2017 - ASBMB
The spice turmeric, with its active polyphenol curcumin, has been used as anti-inflammatory
remedy in traditional Asian medicine for centuries. Many cellular targets of curcumin have …