Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

In patients with heart failure (HF), the neuroendocrine systems of the sympathetic nervous
system (SNS), the renin–angiotensin–aldosterone system (RAAS) and the arginine …

Local signaling domains and numerous interacting molecular pathways and substrates
contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS) …

Atrial fibrillation (AF) is the most common cardiac arrhythmia, and it causes substantial
mortality. The autonomic nervous system, and particularly the adrenergic/cholinergic …

Abnormalities in repolarization and its rate dependence are known to be related to
increased proarrhythmic risk. A number of repolarization-related electrophysiological …

It has long been recognized that increased sympathetic nerve activity during physiologic
stress (exercise, swimming, emotion, arousal, loud noise, etc.) has profound influences on …

Sudden death among athletes is very rare (1: 50,000–1: 100,000 annually) but it is still 2–4
times more frequent than in the age-matched control population and attracts significant …

Proarrhythmic susceptibility to drug-induced Torsades de Pointes is restricted to individuals
with a predisposed phenotype characterized by a reduced repolarization reserve. Additional …

Objective: Acquired long-QT syndrome in combination with increased beat-to-beat variability
of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias …