[HTML][HTML] Airway remodeling in asthma

KP Hough, ML Curtiss, TJ Blain, RM Liu, J Trevor… - Frontiers in …, 2020 - frontiersin.org
Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Obesity-related asthma in children and adolescents

J Reyes-Angel, P Kaviany, D Rastogi… - The Lancet Child & …, 2022 - thelancet.com
There is substantial epidemiological and experimental evidence of an obesity-related
asthma phenotype. Compared to children of healthy weight, children with obesity are at …

Addressing disparities in lung cancer screening eligibility and healthcare access. An official American Thoracic Society statement

MP Rivera, HA Katki, NT Tanner, M Triplette… - American journal of …, 2020 - atsjournals.org
Background: There are well-documented disparities in lung cancer outcomes across
populations. Lung cancer screening (LCS) has the potential to reduce lung cancer mortality …

[HTML][HTML] Risankizumab in severe asthma—a phase 2a, placebo-controlled trial

CE Brightling, P Nair, DJ Cousins… - New England Journal …, 2021 - Mass Medical Soc
Background Interleukin-23 has been implicated in airway inflammation that is mediated by
type 2 and type 17 cytokines. Whether targeting interleukin-23 in the treatment of asthma …

The genetics of asthma and the promise of genomics-guided drug target discovery

ZW El-Husseini, R Gosens, F Dekker… - The Lancet …, 2020 - thelancet.com
Asthma is an inflammatory airway disease that is estimated to affect 339 million people
globally. The symptoms of about 5–10% of patients with asthma are not adequately …

[HTML][HTML] Asthma and obesity: two diseases on the rise and bridged by inflammation

M Bantulà, J Roca-Ferrer, E Arismendi… - Journal of clinical …, 2021 - mdpi.com
Asthma and obesity are two epidemics affecting the developed world. The relationship
between obesity and both asthma and severe asthma appears to be weight-dependent …

Severe adult asthmas: integrating clinical features, biology, and therapeutics to improve outcomes

SE Wenzel - American journal of respiratory and critical care …, 2021 - atsjournals.org
Evaluation and effective management of asthma, and in particular severe asthma, remains
at the core of pulmonary practice. Over the last 20–30 years, there has been increasing …

[HTML][HTML] New perspectives for mucolytic, anti-inflammatory and adjunctive therapy with 1, 8-cineole in COPD and asthma: review on the new therapeutic approach

LJ Juergens, H Worth, UR Juergens - Advances in therapy, 2020 - Springer
Abstract The mucolytic monoterpene 1, 8-cineole (eucalyptol), the major constituent of
eucalyptus species, is well known for its anti-inflammatory, antioxidant, bronchodilatory …

Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD

AA Calderon, C Dimond, DF Choy… - European …, 2023 - Eur Respiratory Soc
Interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) are alarmins that are
released upon airway epithelial injury from insults such as viruses and cigarette smoke, and …

Air− liquid Interface cultures of the healthy and diseased human respiratory tract: promises, challenges, and future directions

D Baldassi, B Gabold, OM Merkel - Advanced nanobiomed …, 2021 - Wiley Online Library
Air− liquid interface (ALI) culture models currently represent a valid instrument to recreate
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …