Aβ-oligomers: A potential therapeutic target for Alzheimer's disease
The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …
Previous research has established amyloid plaque deposition as the leading cause of …
Harnessing the Therapeutic Potential of Peptides for Synergistic Treatment of Alzheimer's Disease by Targeting Aβ Aggregation, Metal-Mediated Aβ Aggregation …
Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative disease and
remains a formidable global health challenge. The current medication for AD gives …
remains a formidable global health challenge. The current medication for AD gives …
Succinate and inosine coordinate innate immune response to bacterial infection
M Jiang, Z Chen, H Li, T Zhang, M Yang, X Peng… - PLoS …, 2022 - journals.plos.org
Macrophages restrict bacterial infection partly by stimulating phagocytosis and partly by
stimulating release of cytokines and complement components. Here, we treat macrophages …
stimulating release of cytokines and complement components. Here, we treat macrophages …
Synthesis and mechanistic study of Aβ42 C-terminus domain derived tetrapeptides that inhibit Alzheimer's Aβ-aggregation-induced neurotoxicity
N Sehra, R Parmar, IK Maurya, V Kumar, K Tikoo… - Bioorganic & Medicinal …, 2024 - Elsevier
Amyloid plaque formation in the brain is mainly responsible for the onset of Alzheimer's
disease (AD). Structure-based peptides have gained importance in recent years, and …
disease (AD). Structure-based peptides have gained importance in recent years, and …
Tailoring of L-cysteine conjugated chitosan carbon electrode for selective and sensitive monitor of copper in the water
Copper has been widely used in bacteriostatic materials and pesticides, which make it as a
potential threat for human health. The development of an electrochemical sensor with high …
potential threat for human health. The development of an electrochemical sensor with high …
Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition
Alzheimer's disease (AD) is the most prevalent neurodegenerative dementia, marked by
progressive cognitive decline and memory impairment. Despite advances in therapeutic …
progressive cognitive decline and memory impairment. Despite advances in therapeutic …
Alleviating neuronal inflammation induced by Aβ42 in SH-SY5Y through interaction with polysialic acid–oligomannuronate conjugate
Amyloid beta (Aβ) aggregation is one of the distinctive pathological hallmarks of Alzheimer's
disease (AD). Therefore, the development of effective inhibitors against Aβ aggregate …
disease (AD). Therefore, the development of effective inhibitors against Aβ aggregate …
Morphology Transition of Tripeptides from Porous Spherical to Rod-like Nanostructures for Small-Molecule Adsorption
Peptides possess a remarkable propensity to adopt distinct morphologies, ranging from
simple aggregates to complex structures such as fibrils and nanotubes. Morphology …
simple aggregates to complex structures such as fibrils and nanotubes. Morphology …
Novel Insights Into DLAT's Role in Alzheimer's Disease‐Related Copper Toxicity Through Microglial Exosome Dynamics
X Ma, Y Sun, C Li, M Wang, Q Zang… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Alzheimer's disease (AD) is a complex neurodegenerative disorder, with recent
research emphasizing the roles of microglia and their secreted extracellular vesicles in AD …
research emphasizing the roles of microglia and their secreted extracellular vesicles in AD …
Peptide-based amyloid-beta aggregation inhibitors
N Sehra, R Parmar, R Jain - RSC Medicinal Chemistry, 2025 - pubs.rsc.org
Aberrant protein misfolding and accumulation is considered to be a major pathological pillar
of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases …
of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases …