Aβ-oligomers: A potential therapeutic target for Alzheimer's disease

S Ghosh, R Ali, S Verma - International Journal of Biological …, 2023 - Elsevier
The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …

Harnessing the Therapeutic Potential of Peptides for Synergistic Treatment of Alzheimer's Disease by Targeting Aβ Aggregation, Metal-Mediated Aβ Aggregation …

K Singh, A Kaur, B Goyal, D Goyal - ACS Chemical Neuroscience, 2024 - ACS Publications
Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative disease and
remains a formidable global health challenge. The current medication for AD gives …

Succinate and inosine coordinate innate immune response to bacterial infection

M Jiang, Z Chen, H Li, T Zhang, M Yang, X Peng… - PLoS …, 2022 - journals.plos.org
Macrophages restrict bacterial infection partly by stimulating phagocytosis and partly by
stimulating release of cytokines and complement components. Here, we treat macrophages …

Synthesis and mechanistic study of Aβ42 C-terminus domain derived tetrapeptides that inhibit Alzheimer's Aβ-aggregation-induced neurotoxicity

N Sehra, R Parmar, IK Maurya, V Kumar, K Tikoo… - Bioorganic & Medicinal …, 2024 - Elsevier
Amyloid plaque formation in the brain is mainly responsible for the onset of Alzheimer's
disease (AD). Structure-based peptides have gained importance in recent years, and …

Tailoring of L-cysteine conjugated chitosan carbon electrode for selective and sensitive monitor of copper in the water

S Gong, X Liu, H Liao, X Lin, Q Huang, M Hasan… - Materials Today …, 2023 - Elsevier
Copper has been widely used in bacteriostatic materials and pesticides, which make it as a
potential threat for human health. The development of an electrochemical sensor with high …

Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition

J Yoo, J Lee, B Ahn, J Han, MH Lim - Chemical Science, 2025 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative dementia, marked by
progressive cognitive decline and memory impairment. Despite advances in therapeutic …

Alleviating neuronal inflammation induced by Aβ42 in SH-SY5Y through interaction with polysialic acid–oligomannuronate conjugate

T Zhang, J Wu, Y Wang, H Zhang, X Zhan - International Journal of …, 2024 - Elsevier
Amyloid beta (Aβ) aggregation is one of the distinctive pathological hallmarks of Alzheimer's
disease (AD). Therefore, the development of effective inhibitors against Aβ aggregate …

Morphology Transition of Tripeptides from Porous Spherical to Rod-like Nanostructures for Small-Molecule Adsorption

S Shill, G Dolai, A Sarkar, B Mandal - Langmuir, 2024 - ACS Publications
Peptides possess a remarkable propensity to adopt distinct morphologies, ranging from
simple aggregates to complex structures such as fibrils and nanotubes. Morphology …

Novel Insights Into DLAT's Role in Alzheimer's Disease‐Related Copper Toxicity Through Microglial Exosome Dynamics

X Ma, Y Sun, C Li, M Wang, Q Zang… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Alzheimer's disease (AD) is a complex neurodegenerative disorder, with recent
research emphasizing the roles of microglia and their secreted extracellular vesicles in AD …

Peptide-based amyloid-beta aggregation inhibitors

N Sehra, R Parmar, R Jain - RSC Medicinal Chemistry, 2025 - pubs.rsc.org
Aberrant protein misfolding and accumulation is considered to be a major pathological pillar
of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases …