5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat
chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of …

Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …

Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute
and chronic pain states, especially in acute postoperative and chronic neuropathic pain …

Chronic pain is long-lasting pain that often persists during chronic diseases or after recovery
from disease or injury. It often causes serious side effects, such as insomnia, anxiety, or …

HT plays a crucial role in the progress and adjustment of pain both centrally and
peripherally. The therapeutic action of the 5-HT receptorsagonist and antagonist in …

Migraine is a neurovascular disorder that involves activation of the trigeminovascular system
and cranial vasodilation mediated by release of calcitonin gene-related peptide (CGRP) …

The monoaminergic system can be manipulated to great effect in the clinic resulting in
improved treatment outcomes and is the basis for the actions of the antidepressant drugs in …

Disruption of the microbiota–gut–brain axis results in a wide range of pathologies that are
affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to …

The 5-HT5A receptor (5-HT5AR), for which no selective agonists and a few antagonists
exist, remains the least understood serotonin receptor. A single commercial antagonist, SB …