[HTML][HTML] Circular RNAs: Characterization, cellular roles, and applications
CX Liu, LL Chen - Cell, 2022 - cell.com
Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs.
Recent technological advances have in part overcome problems with their circular …
Recent technological advances have in part overcome problems with their circular …
Biogenesis and regulatory roles of circular RNAs
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …
Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines
Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …
The expanding regulatory mechanisms and cellular functions of circular RNAs
LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …
The biogenesis, biology and characterization of circular RNAs
LS Kristensen, MS Andersen, LVW Stagsted… - Nature reviews …, 2019 - nature.com
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …
[HTML][HTML] Circular RNA-protein interactions: functions, mechanisms, and identification
Circular RNAs (circRNAs) are covalently closed, endogenous RNAs with no 5′ end caps or
3′ poly (A) tails. These RNAs are expressed in tissue-specific, cell-specific, and …
3′ poly (A) tails. These RNAs are expressed in tissue-specific, cell-specific, and …
Past, present, and future of circ RNA s
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of …
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of …
Targeting mitochondria-located circRNA SCAR alleviates NASH via reducing mROS output
Q Zhao, J Liu, H Deng, R Ma, JY Liao, H Liang, J Hu… - Cell, 2020 - cell.com
Mitochondria, which play central roles in immunometabolic diseases, have their own
genome. However, the functions of mitochondria-located noncoding RNAs are largely …
genome. However, the functions of mitochondria-located noncoding RNAs are largely …
The biogenesis, functions, and challenges of circular RNAs
Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing
of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low …
of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low …